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Concept
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Virus Replication
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Academic Article
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The essential protein encoded by the UL31 gene of herpes simplex virus 1 depends for its stability on the presence of UL34 protein.
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Academic Article
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Herpes simplex virus infections.
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Academic Article
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Replication-competent herpes simplex viral vectors for cancer therapy.
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Academic Article
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Molecular targeting of gene therapy and radiotherapy.
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Academic Article
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Second-site mutation outside of the U(S)10-12 domain of Deltagamma(1)34.5 herpes simplex virus 1 recombinant blocks the shutoff of protein synthesis induced by activated protein kinase R and partially restores neurovirulence.
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Academic Article
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Herpes simplex virus 1 open reading frames O and P are not necessary for establishment of latent infection in mice.
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Academic Article
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Wild-type herpes simplex virus 1 blocks programmed cell death and release of cytochrome c but not the translocation of mitochondrial apoptosis-inducing factor to the nuclei of human embryonic lung fibroblasts.
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Academic Article
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The role of cdc2 in the expression of herpes simplex virus genes.
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Academic Article
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The use of a genetically engineered herpes simplex virus (R7020) with ionizing radiation for experimental hepatoma.
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Academic Article
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Engineered herpes simplex virus 1 is dependent on IL13Ralpha 2 receptor for cell entry and independent of glycoprotein D receptor interaction.
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Academic Article
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The carboxyl-terminal domain of RNA polymerase II is phosphorylated by a complex containing cdk9 and infected-cell protein 22 of herpes simplex virus 1.
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Academic Article
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The stress-inducible immediate-early responsive gene IEX-1 is activated in cells infected with herpes simplex virus 1, but several viral mechanisms, including 3' degradation of its RNA, preclude expression of the gene.
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Academic Article
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Herpes simplex virus 1 recombinant virions exhibiting the amino terminal fragment of urokinase-type plasminogen activator can enter cells via the cognate receptor.
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Academic Article
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Activated MEK suppresses activation of PKR and enables efficient replication and in vivo oncolysis by Deltagamma(1)34.5 mutants of herpes simplex virus 1.
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Academic Article
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State and role of SRC family kinases in replication of herpes simplex virus 1.
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Academic Article
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Proteolytic cleavage of VP1-2 is required for release of herpes simplex virus 1 DNA into the nucleus.
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Academic Article
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Temperature-sensitive mutations in the putative herpes simplex virus type 1 terminase subunits pUL15 and pUL33 preclude viral DNA cleavage/packaging and interaction with pUL28 at the nonpermissive temperature.
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Academic Article
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Cells lacking NF-kappaB or in which NF-kappaB is not activated vary with respect to ability to sustain herpes simplex virus 1 replication and are not susceptible to apoptosis induced by a replication-incompetent mutant virus.
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Academic Article
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Interwoven roles of cyclin D3 and cdk4 recruited by ICP0 and ICP4 in the expression of herpes simplex virus genes.
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Academic Article
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Systemic delivery of (gamma1)34.5-deleted herpes simplex virus-1 selectively targets and treats distant human xenograft tumors that express high MEK activity.
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Academic Article
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Increased oncolytic efficacy for high-grade gliomas by optimal integration of ionizing radiation into the replicative cycle of HSV-1.
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Academic Article
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Herpes simplex virus-infected cell protein 0 blocks the silencing of viral DNA by dissociating histone deacetylases from the CoREST-REST complex.
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Academic Article
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The histone acetyltransferase CLOCK is an essential component of the herpes simplex virus 1 transcriptome that includes TFIID, ICP4, ICP27, and ICP22.
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Academic Article
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Characterization of a recombinant herpes simplex virus 1 designed to enter cells via the IL13Ralpha2 receptor of malignant glioma cells.
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Academic Article
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The two functions of herpes simplex virus 1 ICP0, inhibition of silencing by the CoREST/REST/HDAC complex and degradation of PML, are executed in tandem.
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Academic Article
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HSV-1 gene expression from reactivated ganglia is disordered and concurrent with suppression of latency-associated transcript and miRNAs.
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Academic Article
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Induction of apoptosis accelerates reactivation of latent HSV-1 in ganglionic organ cultures and replication in cell cultures.
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Academic Article
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Role of cellular phosphatase cdc25C in herpes simplex virus 1 replication.
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Academic Article
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Identification of a novel expressed open reading frame situated between genes U(L)20 and U(L)21 of the herpes simplex virus 1 genome.
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Academic Article
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Overexpression of promyelocytic leukemia protein precludes the dispersal of ND10 structures and has no effect on accumulation of infectious herpes simplex virus 1 or its proteins.
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Academic Article
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Friendly fire: redirecting herpes simplex virus-1 for therapeutic applications.
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Academic Article
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ReVOLT: radiation-enhanced viral oncolytic therapy.
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Academic Article
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ICP0 enables and monitors the function of D cyclins in herpes simplex virus 1 infected cells.
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Academic Article
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HSV carrying WT REST establishes latency but reactivates only if the synthesis of REST is suppressed.
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Academic Article
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The role of the CoREST/REST repressor complex in herpes simplex virus 1 productive infection and in latency.
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Academic Article
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An inquiry into the molecular basis of HSV latency and reactivation.
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Academic Article
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Cells infected with herpes simplex virus 1 export to uninfected cells exosomes containing STING, viral mRNAs, and microRNAs.
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Academic Article
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Interaction of herpes simplex virus ICP0 with ND10 bodies: a sequential process of adhesion, fusion, and retention.
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Academic Article
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HSV-1 degrades, stabilizes, requires, or is stung by STING depending on ICP0, the US3 protein kinase, and cell derivation.
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Academic Article
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The stability of herpes simplex virus 1 ICP0 early after infection is defined by the RING finger and the UL13 protein kinase.
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Academic Article
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The 3 facets of regulation of herpes simplex virus gene expression: A critical inquiry.
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Academic Article
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miR-H28 and miR-H29 expressed late in productive infection are exported and restrict HSV-1 replication and spread in recipient cells.
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Academic Article
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PML plays both inimical and beneficial roles in HSV-1 replication.
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Academic Article
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miRNAs Targeting ICP4 and Delivered to Susceptible Cells in Exosomes Block HSV-1 Replication in a Dose-Dependent Manner.
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Academic Article
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Innate responses to gene knockouts impact overlapping gene networks and vary with respect to resistance to viral infection.
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Academic Article
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GADD45? Activated Early in the Course of Herpes Simplex Virus 1 Infection Suppresses the Activation of a Network of Innate Immunity Genes.
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Academic Article
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Herpes Simplex Virus 1 MicroRNA miR-H28 Exported to Uninfected Cells in Exosomes Restricts Cell-to-Cell Virus Spread by Inducing Gamma Interferon mRNA.
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Academic Article
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hnRNPA2B1 Associated with Recruitment of RNA into Exosomes Plays a Key Role in Herpes Simplex Virus 1 Release from Infected Cells.
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Grant
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Engineered HSV For Treatment of Malignant Glioma
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